Pathology Research, learning about Dementia from Brain Tissue & the Brain Bank
Dementia Research Charity Chatathon
12/09/22
•29m
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Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Lauren Walker, ARUK Research Fellow at Newcastle University, Dr Megan Torvell, Research Associate in the UK Dementia Research Institute at Cardiff University, Dr Keeley Brookes-Baker, Senior Lecturer at Nottingham Trent University and Joe Morgan a PhD Student from University of Salford.
Dr Lauren Walker - My main research interests lie in investigating the effects of multiple pathological lesions on clinical phenotype in neurodegenerative disorders (e.g. Alzheimer's disease and Lewy body disease). Using a quantitative clinico-patholigical approach I aim to tease is distinct clinico-pathologcal phenotypes which may ultimately lead to tailored treatment options for patients. To complete this work, I use donated human brain tissue from Newcastle Brain Tissue Resource and the Brains for Dementia Research initiative.
Dr Megan Torvell - My research uses human postmortem tissue and genetically modified mouse models to understand the role of complement, an important branch of the innate immune system, in Alzheimer's disease.
Dr Keeley Brookes - My research focuses on producing genetic data and analysis for the Brains for Dementia Research (BDR) Project to be used in conjunction with other data generated on this cohort to bridge the gap between genetic risk for dementia and phenotype. My current studies are to try and align current polygenic risk score models with biological outcomes, in order to refine the model to the most relevant genetic variants, therefore increasing the accuracy of the score to predict genetic risk and identify those genes that may be actionable targets for therapeutic intervention.
Joe Morgan - My research is based on investigating the relationship between autophagy and small extrscellular vesicle miRNA cargoes in Alzheimer’s disease and frontotemporal dementia.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
Previous Episode
Caring Dementia Care in Care Homes
December 9, 2022
•30m
Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Professor Claire Surr, Professor of Dementia Studies at Leeds Beckett University and Dr Victoria Shepherd, Senior Research Fellow, Cardiff University.
Professor Claire Surr - I am Director of the Centre for Dementia Research, a cross-University research Centre dedicated to supporting multi-disciplinary applied dementia research. I have led a wide range of dementia research programmes funded by major funders including the National Institute for Health Research and the Alzheimer's Society. I work in dementia care and services research. Most recently my focus has been on dementia and comorbidity, care homes and workforce education and training.
Dr Victoria Shepherd - I lead an interdisciplinary programme of research exploring the ethical and methodological issues around research involving adults with impaired capacity to consent, including people living with dementia. This includes the recent development of the NIHR INCLUDE Impaired Capacity to Consent Framework to help researchers to design trials that are more inclusive of people who may experience challenges around consent. Alongside this, I have a broad portfolio of methodological research including care home studies such as COS COVID PCARE which established the core outcomes to be measured in trials evaluating interventions to prevent COVID-19 in care homes.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
Next Episode
Misfolded Proteins, Nanoparticles to bust Amyloid & Neurovascular Functions
December 9, 2022
•28m
Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Eric Dyne, Clinical Specialist at Roche Diagnostics, Louise Serpell, Professor of Biochemistry at University of Sussex and Beth Eyre, PhD Student at The University of Sheffield.
Dr Eric Dyne - My research involved the use of nanoparticles to target beta-amyloid plaques but current interest and specialisation is biomarkers and diagnostics for Alzheimer's disease and ADRDs.
Professor Louise Serpell - I lead a team of researchers, investigating the causes of dementia, we are interested in causes of AD and what the involvement of amyloidbeta and tau is at a molecular level.
Beth Eyre - My research focuses on something we call neurovascular function, which is the relationship between neurons and blood flow in the brain. During my PhD I have been looking at the effects of heart disease, Alzheimer's disease and both diseases together and the effect these disease have on neurovascular function.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
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