Misfolded Proteins, Nanoparticles to bust Amyloid & Neurovascular Functions
Dementia Research Charity Chatathon
12/09/22
•28m
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Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Eric Dyne, Clinical Specialist at Roche Diagnostics, Louise Serpell, Professor of Biochemistry at University of Sussex and Beth Eyre, PhD Student at The University of Sheffield.
Dr Eric Dyne - My research involved the use of nanoparticles to target beta-amyloid plaques but current interest and specialisation is biomarkers and diagnostics for Alzheimer's disease and ADRDs.
Professor Louise Serpell - I lead a team of researchers, investigating the causes of dementia, we are interested in causes of AD and what the involvement of amyloidbeta and tau is at a molecular level.
Beth Eyre - My research focuses on something we call neurovascular function, which is the relationship between neurons and blood flow in the brain. During my PhD I have been looking at the effects of heart disease, Alzheimer's disease and both diseases together and the effect these disease have on neurovascular function.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
Previous Episode
Pathology Research, learning about Dementia from Brain Tissue & the Brain Bank
December 9, 2022
•29m
Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Lauren Walker, ARUK Research Fellow at Newcastle University, Dr Megan Torvell, Research Associate in the UK Dementia Research Institute at Cardiff University, Dr Keeley Brookes-Baker, Senior Lecturer at Nottingham Trent University and Joe Morgan a PhD Student from University of Salford.
Dr Lauren Walker - My main research interests lie in investigating the effects of multiple pathological lesions on clinical phenotype in neurodegenerative disorders (e.g. Alzheimer's disease and Lewy body disease). Using a quantitative clinico-patholigical approach I aim to tease is distinct clinico-pathologcal phenotypes which may ultimately lead to tailored treatment options for patients. To complete this work, I use donated human brain tissue from Newcastle Brain Tissue Resource and the Brains for Dementia Research initiative.
Dr Megan Torvell - My research uses human postmortem tissue and genetically modified mouse models to understand the role of complement, an important branch of the innate immune system, in Alzheimer's disease.
Dr Keeley Brookes - My research focuses on producing genetic data and analysis for the Brains for Dementia Research (BDR) Project to be used in conjunction with other data generated on this cohort to bridge the gap between genetic risk for dementia and phenotype. My current studies are to try and align current polygenic risk score models with biological outcomes, in order to refine the model to the most relevant genetic variants, therefore increasing the accuracy of the score to predict genetic risk and identify those genes that may be actionable targets for therapeutic intervention.
Joe Morgan - My research is based on investigating the relationship between autophagy and small extrscellular vesicle miRNA cargoes in Alzheimer’s disease and frontotemporal dementia.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
Next Episode
Dementia - Faith, Communication & Primary Progressive Aphasia
December 9, 2022
•35m
Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Anna Volkmer, Senior Research Fellow & Speech and Language Therapist at University College London, Dr Katherine Britt, Postdoctoral Research Fellow at University of Pennsylvania and Professor Cindy Weinstein, GBHI Fellow and Eli & Edythe Professor of English, Caltech, USA.
Dr Anna Volkmer - I am interested a speech and language therapist who has specialised in working with people with dementia and their families. My research focuses on developing speech and language interventions for people with primary progressive aphasia (PPA) and other dementias (inc Alzheimer's disease). I am passionate about conversation and supporting people and their families to be able interact "better". This also includes exploring how we measure what is important to people living with PPA and dementia and their families.
Dr Katherine Carroll Britt - I recently graduated with my PhD from The University of Texas. My work focuses on the utilisation of religion and spirituality for coping during stress and illness and how religious and spiritual practices impact mental and physical health, mainly in older adults including those with cognitive impairment, dementia, and their caregivers. My most recent work looks at associations of religious service attendance and frequency of private prayer with neuropsychiatric symptoms, cognitive function, and sleep disturbances in dementia and Mild Cognitive Impairment. I aim to identify protective factors and create nonpharmacologic interventions to slow disease progression and to improve well-being and quality of life in dementia.
Professor Cindy Weinstein - I am an English professor at the California Institute of Technology and an Atlantic Fellow, who studied neurology at the Global Brain Health Institute at UCSF. While there, Dr. Bruce Miller and I wrote a book, Finding the Right Words: A Story of Literature, Grief, and the Brain ( https://bit.ly/3uBO8Ju ), which was published last year by Johns Hopkins University. It is about my father's early onset Alzheimer's, and is told from my perspective as a daughter/English professor and Dr. Miller's as a son/neurologist.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
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