Getting behind some of the Causes of Dementia - Sleep, Diet, Genes and more
Dementia Research Charity Chatathon
01/13/23
•26m
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On the 7th September 2020, Adam Smith hosted the Dementia Research Chatathon LIVE - to share information on the wide variety of research taking place across the world, and the raise money for Alzheimer's Research UK. Please continue to donate and help Adam meet his £5,000 target - details can be found at www.chatathon.uk.
In a way that everyone can understand, this video features Adam talking with:
Dr Christina Toomey, Post-doctoral Research Associate, University College London. Christina's research focuses on the proteomics and lipidomics of neurodegenerative diseases and the link to the pathology present. My PhD was on the role TREM2 Gene plays in neurodegeneration too - @christina_neuro.
Dr Guliz Ozcan, Postdoctoral Research Associate, University College London. Guliz works at the interception of sleep and Alzheimer's disease. Sleep problems are one of the earliest symptoms of AD and often arise years before the cognitive deficits. Using zebrafish, we have recently shown that Aβ acutely and reversibly enhances or suppresses sleep as a function of oligomer length - @guilizozcan.
Dr Gemma Lace, Senior Lecturer in Biomedical Science & Lead of Public Engagement and Outreach, University of Salford. Gemma researchers the role of autophagy impairments in Alzheimer's disease and frontotemporal dementia, the role of obesity in dementia risk and how exosomes may shed light on underlying disease mechanisms and be used as diagnostic biomarkers. A large part her job is to also raise dementia awareness through outreach and public engagement events - @gemmalace
Previous Episode
Epigenetics, Exploring Dark crevices of Genes and links to Alzheimer's
January 12, 2023
•28m
On the 7th September 2020, Adam Smith hosted the Dementia Research Chatathon LIVE - to share information on the wide variety of research taking place across the world, and the raise money for Alzheimer's Research UK. Please continue to donate and help Adam meet his £5,000 target - details can be found at www.chatathon.uk.
In a way that everyone can understand, this video features Adam talking with:
Professor Katie Lunnon, Professor of Dementia Genomics, University of Exeter. Katie works in the field of epigenetics and gene regulation. Her studies look in the brain to see if we can identify epigenetic differences in individuals with dementia as well as in the blood with the hope of identifying new biomarkers. Initially focusing on Alzheimer's disease but now expanding her studies to look at other dementias as well. Additionally Katie leads a number of functional studies, exploring proteins, iPSCs and gene editing in cell lines - @katielunnon
Dr Leonidas Chouliaras, Clinical Lecturer in Old Age Psychiatry, University of Cambridge. Leo is a clinician and epigeneticist, focused on Lewy Body Dementia. Working both on clinical cohorts, studying DNA methylation in blood samples as well as in autopsy brain tissues, isolating neurons with Lewy Bodies using laser-microdissection and comparing the epigenetic profiles with healthy looking neurons from the same donor or from controls - @chouliarasL
Next Episode
Neuropeptides, Cells and Dipeptides - Water Parks & Messaging in the Brain
January 17, 2023
•27m
On the 7th September 2020, Adam Smith hosted the Dementia Research Chatathon LIVE - to share information on the wide variety of research taking place across the world, and the raise money for Alzheimer's Research UK. Please continue to donate and help Adam meet his £5,000 target - details can be found at www.chatathon.uk.
In a way that everyone can understand, this video features Adam talking with:
Dr Emily Maguire, Research Associate, UK Dementia Research Institute at Cardiff University. Emily researches the use of human stem cells which she differentiates into brain cells to understand the pathology of Alzheimer's disease.
Dr Sarah Ryan, Alzheimer's Society Research Fellow, University of Manchester. Sarah is investigating mechanisms of neurodegeneration in C9orf72 FTD, particularly those caused by the dipeptides arising from the C9 expansion - @geekazoid.
Dr James Quinn, Neurology Research Fellow, Massachusetts General Hospital, USA (moved since recording). James studies neuropeptides in neurodegenerative and psychiatric diseases to unravel disease mechanisms, working to identify new diagnostic biomarkers (something that indicated someone had dementia, and the type), and novel therapeutic targets - @tweetwithquin.
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