Genomics and Big Data to find new Dementia Medicines & help Diagnosis
Dementia Research Charity Chatathon
12/09/22
•24m
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Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Danielle Newby, Postdoctoral Data Scientist and Dr Laura Winchester, Alzheimer's Research UK Fellow both from University of Oxford.
Dr Danielle Newby - Based within the Centre for Statistics in Medicine at Oxford. One of my areas of research is now generating evidence about the safety of medicines in people living with dementia and parkinson's disease across the UK and Europe using real world evidence (i.e. medical records). This evidence can be used to help improve decision making by clinicians about the drugs they prescribe and utimately improve the quality of life of these patients.
Dr Laura Winchester - I am interested in the application of large-scale multi-omics data to better understand disease variants and therapeutics. This involves using genomic and proteomic data analysis from Alzheimer’s Disease, Parkinson’s Disease and healthy population cohorts to develop new biomarkers and understand dementia mechanisms by applying integrative and machine learning methodologies. I use all these informatics approaches in my main research focus: the study of the relationship between iron homeostasis and dementia.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
Previous Episode
Biomarkers - Diagnosing Dementias with a Drop of Blood
December 9, 2022
•33m
Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Amanda Heslegrave, Senior Research Fellow at the UK Dementia Research Institute, UCL, Dr Nicholas Ashton, Assistant Professor of Neurochemistry at University Gothenburg & King's College London and Dr Aitana Sogorb-Esteve, Race Against Dementia / ARUK Fellow at University College London.
Dr Amanda Heslegrave - I collaborate with clinical researchers to measure biomarkers of neurodegeneration in a variety of biofluids, most topical right now are blood biomarkers which we are able to measure with the use of super sensitive assay technology - overall I focus on Fluid Biomarkers, diagnostics, prognostics, response to therapeutics.
Dr Nicholas Ashton - I have over decade of experience in biofluid analysis and assay development for Alzheimer’s disease and related disorder which ranges from discovery mass spectrometry methods to ultra-sensitive immunoassays development. Recently, this has seen the success of assays specific for phosphorylated tau and neurofilament light, which being evaluated for clinical routine across Europe and inclusion criterion for clinical trials targeting dementia. I have published over 100 original research articles in fluid biomarker for neurogenerative diseases.
Dr Aitana Sogorb-Esteve - My expertise is in fluid biomarkers and specifically I am looking for novel markers to assess synaptic dysfunction in genetic FTD. I have had promising results in Cerebrospinal fluid and my aim now is to measure such synaptic markers in blood by extracting neuronal-derived extracellular vesicles from plasma samples in the GENFI cohort.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
Next Episode
Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Anna Sanchez Avila, PhD Student from University of Dundee and Rebecca Williams, PhD Student in the MRC Cognition & Brain Sciences Unit at University of Cambridge.
Anna Sanchez Avila - I work in the field of motor neuron disease and frontotemporal dementia, which have more in common than you might think. I use high-resolution microscopy techniques to look at how synapses - small, delicate structures that allow our brain cells to communicate with each other - change in disease. I want to also see if those changes happen all over the brain or in specific regions that correlate with the symptoms we see.
Rebecca Williams - I study apathy in conditions associated with frontotemporal degeneration, using a combination of Magnetoencephalography (MEG) imaging, Bayesian frameworks (The Bayesian framework uses metered data to infer the most likely distribution of the modeling parameters) and computational modelling.
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The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.
This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.
For more information and to donate visit http://www.chatathon.uk
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