Investigating the ubiquitin proteasome system

Dementia Researcher Vodcast

08/15/21

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49m

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In today’s podcast Professor Selina Wray from University College London, meets four early career researchers, who know a great deal about the brain, human iPSC derived cells and the ubiquitin-proteasome pathway (not that isn’t a new type of electric car).

We’ll be discussing their research, discovering more about super resolution microscopy, and how they’re researching the ubiquitin proteasome system, and its connection to dementia.

We’re delighted to welcome our guests:

PhD Students Liina Sirvio, Katiuska Daniela Pulgar Prieto from the UK Dementia Research Institute at Imperial College London. Georgie Lines, PhD Student from University College London and Dr Emma Mee Hayes a Postdoctoral Research Associate also from the UK Dementia Research Institute at Imperial College London.

What is the purpose of ubiquitin proteasome system?

In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development.

A transcript of this show, links and show notes and profile on all our guests are available on our website at https://www.dementiaresearcher.nihr.ac.uk.

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Previous Episode

AAIC 2021 Round-up - Live Plenary

August 1, 2021

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60m

In this episode we share a recording of the AAIC Highlights live plenary session, organised and delivered as part of the conference on 30th July. Session chairs Dr Rebecca Edelmayer & Dr Percy Griffin from Alzheimer's Association speak with panellists Wagner Brum, Karen Dorsman, Alexander Ehrenberg, Dr Maureen Okafor and Dr Anna Volkmer To see the live recording of this session, and more from the conference visit https://www.alz.org/aaic Details on the guest from this recording, and a full transcription can be found on our website - https://www.dementiaresearcher.nihr.ac.uk/podcasts Thank you to Alzheimer's Association for giving us permission to share this recording - please note that this audio should not be copied or duplicated, and the views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of the Alzheimer's Association. _________________________ Finally, please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. Register on our website to receive your weekly bulletin, and to access more great content – blogs, science, career support + much more https://www.dementiaresearcher.nihr.ac.uk This podcast is brought to you in association with Alzheimer's Research UK and Alzheimer's Society, who we thank for their ongoing support.

Next Episode

Food For Thought - Eating for brain health with Dr Neal Barnard

August 29, 2021

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47m

This week Dr Sam Moxon interviews Dr Neal Barnard, American author, clinical researcher, Leading TED Talk speaker and founding president of the Physicians Committee for Responsible Medicine (PCRM).

They discuss the affected of diet on the brain, and the importance of what you eat on brain and overall health. Dr. Barnard has led numerous research studies investigating the effects of diet on diabetes, body weight, the brain and chronic pain, including a ground-breaking study of dietary interventions in type 2 diabetes - paving the way for viewing type 2 diabetes as a potentially reversible condition. He has authored more than 100 scientific publications and 20 books (including some of the best ever selling Vegan health books) for medical and lay readers, and is the editor in chief of the Nutrition Guide for Clinicians, a textbook made available to all U.S. medical students.

As president of the Physicians Committee, Dr Barnard also leads programs advocating for preventive medicine, good nutrition, and higher ethical standards in research. His research contributed to the acceptance of plant-based diets in the Dietary Guidelines for Americans, and in 2015, he was named a Fellow of the American College of Cardiology. In 2016, he founded the Barnard Medical Center in Washington, D.C., as a model for making nutrition a routine part of all medical care. Working with the Medical Society of the District of Columbia and the American Medical Association, Dr. Barnard has authored key resolutions, now part of AMA policy, calling for a new focus on prevention and nutrition in federal policies and in medical practice. In 2018, he received the Medical Society of the District of Columbia’s Distinguished Service Award. He has hosted four PBS television programs on nutrition and health.

This episode is sponsored by Famileo. Helping families living with dementia stay close with a personalised printed magazine, delivered monthly. Over a quarter of a million families already use Famileo to stay connected. First month free with code DR26. Visit their website at famileo.com